发明申请
- 专利标题： NOVEL SIGNATURE SELF RENEWAL GENE EXPRESSION PROGRAMS
- 专利标题（中）： 新签署自我更新基因表达程序
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申请号： US12294195申请日： 2007-03-26
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公开(公告)号： US20090324618A1公开(公告)日： 2009-12-31
- 发明人: Scott A. Armstrong , Andrei V. Krivtsov
- 申请人： Scott A. Armstrong , Andrei V. Krivtsov
- 国际申请： PCT/US07/07448 WO 20070326
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12Q1/68 ; A61K31/7088 ; A61K31/7105 ; C12N5/06 ; G01N33/574
摘要：
The present invention relates to compounds and methods which are useful in molecular investigations of target genes, as well as their encoded RNAs and protein, belonging to signature self renewal programs in leukemia and/or cancer stem cells. Data herein shows that leukemia stem cells can be generated from committed progenitors without widespread reprogramming of gene expression, and wherein a leukemia self-renewal associated signature is activated in the process.
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