发明申请
US20090325883A1 Peptides Which Interact with Anti-Apoptotic Members of the BCL-2 Protein Family, and Uses
失效
与BCL-2蛋白家族的抗凋亡成员相互作用的肽及其用途
- 专利标题： Peptides Which Interact with Anti-Apoptotic Members of the BCL-2 Protein Family, and Uses
- 专利标题（中）： 与BCL-2蛋白家族的抗凋亡成员相互作用的肽及其用途
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申请号： US11883400申请日： 2006-01-31
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公开(公告)号： US20090325883A1公开(公告)日： 2009-12-31
- 发明人: Olivier Geneste , John Hickman , Jean-Christophe Rain
- 申请人： Olivier Geneste , John Hickman , Jean-Christophe Rain
- 申请人地址： FR Courbevoie Cedex FR Paris
- 专利权人： Les Laboratoires Servier,Hybrigenics
- 当前专利权人： Les Laboratoires Servier,Hybrigenics
- 当前专利权人地址： FR Courbevoie Cedex FR Paris
- 优先权： FR0500978 20050201
- 国际申请： PCT/FR2006/000206 WO 20060131
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/00 ; C07H21/00 ; C07H21/04 ; C12N15/63 ; C12N1/21 ; C12N5/10 ; G01N33/566
摘要：
The invention lies within the field of seeking out and identifying new peptides which interact with anti-apoptotic members of the Bcl-2 protein family, by means of the two-hybrid system.The invention relates to a method of screening and identifying modulators of the protein interaction between those new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.
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