发明申请
US20100004452A1 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.
审中-公开
5-Quinolinone衍生物作为5HT1A受体调节剂,用于治疗性功能障碍,认知障碍,心理障碍,异常,呕吐等。
- 专利标题: 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.
- 专利标题(中): 5-Quinolinone衍生物作为5HT1A受体调节剂,用于治疗性功能障碍,认知障碍,心理障碍,异常,呕吐等。
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申请号: US12442148申请日: 2007-09-24
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公开(公告)号: US20100004452A1公开(公告)日: 2010-01-07
- 发明人: Barbara Bertani , Steven Mark Bromidge , Massimo Gianotti , Alessandra Pasquarello , Valeria Zucchelli
- 申请人: Barbara Bertani , Steven Mark Bromidge , Massimo Gianotti , Alessandra Pasquarello , Valeria Zucchelli
- 优先权: GB0618949.2 20060926; GB0712147.8 20070622
- 国际申请: PCT/EP2007/060082 WO 20070924
- 主分类号: C07D401/14
- IPC分类号: C07D401/14
摘要:
Disclosed are compounds of formula (I) wherein R1 is C1-6alkyl, halo or haloC1-6alkyl; R2 is hydrogen or C1-6alkyl; is a single or double bond; each R3 and R4, which may be the same or different, are hydrogen, C1-6alkyl or haloC1-6alkyl; wherein i) when is a double bond p and q are 1, and ii) when is a single bond, p and q are 2, and one of R3 and one of R4, together with their interconnecting atoms, forms a cyclopropane ring which may be substituted by one or two halo or methyl groups, which groups may be the same or different; X is CH or N; when present each R5, which may be the same or different, is C1-6alkyl or halo; or two R5 groups may join to form a bridge, which bridge contains one or two atoms; n is 0, 1, 2 or 3; when present each R6 which may be the same or different, is C1-6alkyl or halo; and m is 0, 1, 2 or 3.