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    5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.
    1.
    发明申请
    5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. 审中-公开
    5-Quinolinone衍生物作为5HT1A受体调节剂，用于治疗性功能障碍，认知障碍，心理障碍，异常，呕吐等。

    公开(公告)号：US20100004452A1

    公开(公告)日：2010-01-07

    申请号：US12442148

    申请日：2007-09-24

    申请人： Barbara Bertani ,  Steven Mark Bromidge ,  Massimo Gianotti ,  Alessandra Pasquarello ,  Valeria Zucchelli

    发明人： Barbara Bertani ,  Steven Mark Bromidge ,  Massimo Gianotti ,  Alessandra Pasquarello ,  Valeria Zucchelli

    IPC分类号： C07D401/14

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D487/08

    摘要： Disclosed are compounds of formula (I) wherein R1 is C1-6alkyl, halo or haloC1-6alkyl; R2 is hydrogen or C1-6alkyl; is a single or double bond; each R3 and R4, which may be the same or different, are hydrogen, C1-6alkyl or haloC1-6alkyl; wherein i) when is a double bond p and q are 1, and ii) when is a single bond, p and q are 2, and one of R3 and one of R4, together with their interconnecting atoms, forms a cyclopropane ring which may be substituted by one or two halo or methyl groups, which groups may be the same or different; X is CH or N; when present each R5, which may be the same or different, is C1-6alkyl or halo; or two R5 groups may join to form a bridge, which bridge contains one or two atoms; n is 0, 1, 2 or 3; when present each R6 which may be the same or different, is C1-6alkyl or halo; and m is 0, 1, 2 or 3.

    摘要翻译： 公开了式（I）的化合物，其中R 1是C 1-6烷基，卤素或卤代C 1-6烷基; R2是氢或C1-6烷基; “img id =”CUSTOM-CHARACTER-00001“he =”2.79mm“wi =”6.35mm“file =”US20100004452A1-20100107-P00001.TIF“img-content =”character“img-format =”tif“/> 是单键或双键; 每个R 3和R 4可以相同或不同，是氢，C 1-6烷基或卤代C 1-6烷基; 其中i）当是双键p，q是1，ii）当是单键，p和q是2，R 3和R 4中的一个连同它们的互连原子一起形成环丙烷环， 被一个或两个卤素或甲基取代，这些基团可以相同或不同; X是CH或N; 当存在时，每个可以相同或不同的R 5是C 1-6烷基或卤素; 或两个R5基团可以连接形成桥，该桥包含一个或两个原子; n为0,1,2或3; 当存在每个可以相同或不同的R 6是C 1-6烷基或卤素时; m为0,1,2或3。

    Novel Compounds
    5.
    发明申请
    Novel Compounds 审中-公开
    新型化合物

    公开(公告)号：US20100227870A1

    公开(公告)日：2010-09-09

    申请号：US12663739

    申请日：2008-06-12

    申请人： Massimo Gianotti ,  Jag Paul Heer ,  Peter John Lovell ,  Catia Seri ,  Ben Gerald Tehan

    发明人： Massimo Gianotti ,  Jag Paul Heer ,  Peter John Lovell ,  Catia Seri ,  Ben Gerald Tehan

    IPC分类号： A61K31/4965 ,  C07D241/04 ,  A61P25/18

    CPC分类号： C07D295/185

    摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for treating diseases and conditions mediated by positive allosteric modulation of the G-protein coupled metabotropic subtype 5 receptor (mGluR5), such as neurological and psychiatric disorders, for example schizophrenia. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，用于治疗由G-蛋白偶联的代谢型5型受体（mGluR5）的正性变构调节介导的疾病和病症，例如神经和精神疾病，例如精神分裂症 。 此外，本发明涉及含有衍生物的组合物及其制备方法。