发明申请
US20100015113A1 GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
有权
GP100特异性T细胞受体及相关材料及其使用方法
- 专利标题： GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
- 专利标题（中）： GP100特异性T细胞受体及相关材料及其使用方法
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申请号： US12522321申请日： 2008-01-11
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公开(公告)号： US20100015113A1公开(公告)日： 2010-01-21
- 发明人: Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
- 申请人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US08/50841 WO 20080111
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; C12N5/08 ; C07K14/725 ; C07K16/18 ; C07H21/04 ; C12N15/63 ; G01N33/53 ; A61P35/04
摘要：
The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
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