发明申请
- 专利标题: PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS
- 专利标题(中): 吡嗪衍生物作为PI3K抑制剂
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申请号: US12298507申请日: 2007-04-25
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公开(公告)号: US20100016306A1公开(公告)日: 2010-01-21
- 发明人: Stewart James Baker , Paul John Goldsmith , Timothy Colin Hancox , Neil Anthony Pegg , Stephen Price , Stephen Joseph Shuttleworth , Sukhjit Sohal
- 申请人: Stewart James Baker , Paul John Goldsmith , Timothy Colin Hancox , Neil Anthony Pegg , Stephen Price , Stephen Joseph Shuttleworth , Sukhjit Sohal
- 申请人地址: CH Basel
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: CH Basel
- 优先权: GB0608264.8 20060426; GB0608397.6 20060427
- 国际申请: PCT/GB07/01504 WO 20070425
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D495/04 ; A61P35/00
摘要:
Thienopyrimidines of formula (Ia) or (Ib): wherein R1-R3 have any of the values described herein, and the pharmaceutically acceptable salt thereof have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase, in particular the p110 delta subtype, such as immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
公开/授权文献
- US08252792B2 Pyrimidine derivatives as PI3K inhibitors 公开/授权日:2012-08-28
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