发明申请
US20100016638A1 Method for preparation of o-desmethylvenlafaxine using polythiolates
审中-公开
使用多硫醇盐制备O-去甲基文拉法辛的方法
- 专利标题： Method for preparation of o-desmethylvenlafaxine using polythiolates
- 专利标题（中）： 使用多硫醇盐制备O-去甲基文拉法辛的方法
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申请号： US12460667申请日： 2009-07-21
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公开(公告)号： US20100016638A1公开(公告)日： 2010-01-21
- 发明人: Zdenko Hamersak , Amir Avdagic
- 申请人： Zdenko Hamersak , Amir Avdagic
- 主分类号： C07C211/27
- IPC分类号： C07C211/27
摘要：
This invention relates to methods of making O-desmethylvenlafaxine from venlafaxine. In the methods venlafaxine is contacted with a polythiolate. The polythiolate may be prepared from the corresponding polythiol in the presence of base. The present methods provide the O-desmethylvenlafaxine in good yields and high purity and are suitable for use on an industrial scale.