发明申请
US20100021963A1 Genetic incorporation of unnatural amino acids into proteins in mammalian cells
有权
在哺乳动物细胞中将非天然氨基酸遗传并入蛋白质中
- 专利标题： Genetic incorporation of unnatural amino acids into proteins in mammalian cells
- 专利标题（中）： 在哺乳动物细胞中将非天然氨基酸遗传并入蛋白质中
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申请号： US12311545申请日： 2007-10-17
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公开(公告)号： US20100021963A1公开(公告)日： 2010-01-28
- 发明人: Wenshe Liu , Peter G. Schultz
- 申请人： Wenshe Liu , Peter G. Schultz
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 国际申请： PCT/US07/22232 WO 20071017
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N5/071 ; C12N5/10
摘要：
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems.
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