发明申请
US20100022547A1 Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
审中-公开
用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法
- 专利标题： Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
- 专利标题（中）： 用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法
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申请号： US12302600申请日： 2007-06-01
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公开(公告)号： US20100022547A1公开(公告)日： 2010-01-28
- 发明人: Lizbeth K. Hedstrom , Boris Striepen
- 申请人： Lizbeth K. Hedstrom , Boris Striepen
- 申请人地址： US MA WALTHAM US GA ATHENS
- 专利权人： BRANDEIS UNIVERSITY,UNIVERSITY OF GEORFIA RESEARCH FOUNDATION
- 当前专利权人： BRANDEIS UNIVERSITY,UNIVERSITY OF GEORFIA RESEARCH FOUNDATION
- 当前专利权人地址： US MA WALTHAM US GA ATHENS
- 国际申请： PCT/US07/70233 WO 20070601
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; A61K31/165 ; C07C233/01 ; A61K31/426 ; C07D277/20 ; A61K31/502 ; C07D237/30 ; A61K31/47 ; C07D215/00 ; A61K31/519 ; C07D495/02 ; A61K31/4184 ; C07D235/02 ; C07D241/36 ; A61K31/4433 ; C07D405/02 ; A61P33/02
摘要：
One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
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