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1.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections 审中-公开用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法公开(公告)号：US20100022547A1
公开(公告)日：2010-01-28
申请号：US12302600
申请日：2007-06-01
IPC分类号： A61K31/498 , A61K31/165 , C07C233/01 , A61K31/426 , C07D277/20 , A61K31/502 , C07D237/30 , A61K31/47 , C07D215/00 , A61K31/519 , C07D495/02 , A61K31/4184 , C07D235/02 , C07D241/36 , A61K31/4433 , C07D405/02 , A61P33/02
CPC分类号： A61K31/4439 , Y02A50/409 , Y02A50/411 , Y02A50/488
摘要： One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本发明的一个方面涉及可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 本发明还提供包含选择性抑制寄生性IMPDH的本发明化合物的药物组合物。 在某些实施方案中，本发明涉及副肌苷-5'-单磷酸脱氢酶对人肌苷-5'-单磷酸脱氢酶（IMPDH I型和II型）的选择性抑制。 这些化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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2.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US20120101096A1
公开(公告)日：2012-04-26
申请号：US13257418
申请日：2010-03-22
申请人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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公开(公告)号：US20130190340A1
公开(公告)日：2013-07-25
申请号：US13805508
申请日：2011-06-30
IPC分类号： C07C279/14 , C07C211/12 , C07C65/40 , C07D239/49 , C07D271/12
CPC分类号： C07C279/14 , A61K31/4184 , A61K31/505 , A61K47/54 , A61K47/542 , A61K47/545 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , Y02A50/469
摘要： Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
摘要翻译： 本发明的某些方面涉及可用于通过增强蛋白质降解来治疗或预防受试者的疾病的化合物，组合物和方法。 在其他方面，所述化合物可用于研究蛋白质降解的有用的研究工具。 在其他方面，所述化合物是调查蛋白质功能的有用的研究工具。 在某些实施方案中，降解的蛋白质涉及疾病或病症，其疾病或病症至少部分地与蛋白质的过度表达或蛋白质的突变形式的表达相关。
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4.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections 审中-公开用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法公开(公告)号：US20120264760A1
公开(公告)日：2012-10-18
申请号：US13490002
申请日：2012-06-06
IPC分类号： A61K31/167 , C07C233/29 , C07D417/04 , A61K31/427 , C07D237/32 , A61K31/502 , C07D215/50 , A61K31/4704 , C07D495/04 , A61K31/519 , C07D235/02 , A61K31/4184 , C07D241/52 , A61K31/498 , C07D405/12 , A61K31/4433 , C07C237/20 , C07D213/75 , A61P33/02 , A61P33/04 , A61K31/4409 , C07C217/84 , A61K31/137 , C07C233/75 , C07C235/24
CPC分类号： A61K31/4439 , Y02A50/409 , Y02A50/411 , Y02A50/488
摘要： One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本发明的一个方面涉及可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 本发明还提供包含选择性抑制寄生性IMPDH的本发明化合物的药物组合物。 在某些实施方案中，本发明涉及副肌苷-5'-单磷酸脱氢酶对人肌苷-5'-单磷酸脱氢酶（IMPDH I型和II型）的选择性抑制。 这些化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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公开(公告)号：US09765019B2
公开(公告)日：2017-09-19
申请号：US13805508
申请日：2011-06-30
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07C279/14 , A61K31/4184 , A61K31/505 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , A61K47/48
CPC分类号： C07C279/14 , A61K31/4184 , A61K31/505 , A61K47/54 , A61K47/542 , A61K47/545 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , Y02A50/469
摘要： Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
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6.发明授权Methods for the development of vaccines based on oligosaccharide-oligonucleotide conjugates 有权基于寡糖 - 寡核苷酸共轭物开发疫苗的方法公开(公告)号：US09080169B2
公开(公告)日：2015-07-14
申请号：US13701849
申请日：2011-06-10
CPC分类号： C07H21/04 , A61K39/21 , A61K47/549 , A61K47/646 , A61K2039/55505 , A61K2039/55511 , A61K2039/6068 , A61K2039/6081 , A61K2039/627 , C07H15/22 , C12N7/00 , C12N15/1048 , C12N15/1058
摘要： Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
摘要翻译： 本文描述了可用作针对一种或多种人或兽医治疗适应症的疫苗的寡糖 - 寡核苷酸缀合物，以及合成和鉴定它们的方法。 可以使用非人抗体作为结合靶标鉴定缀合物，从而扩大本发明的功能和范围。 有效的缀合物可以通过迭代来鉴定。
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7.发明授权Compounds and methods for treating mammalian gastrointestinal microbial infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US08969342B2
公开(公告)日：2015-03-03
申请号：US13257418
申请日：2010-03-22
申请人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Boris Striepen , Suresh Kumar Gorla , Mandapati Kavitha
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Boris Striepen , Suresh Kumar Gorla , Mandapati Kavitha
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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8.发明申请Methods for the Development of Vaccines Based on Oligosaccharide-Oligonucleotide Conjugates 有权基于寡糖 - 寡核苷酸缀合物开发疫苗的方法公开(公告)号：US20130116417A1
公开(公告)日：2013-05-09
申请号：US13701849
申请日：2011-06-10
CPC分类号： C07H21/04 , A61K39/21 , A61K47/549 , A61K47/646 , A61K2039/55505 , A61K2039/55511 , A61K2039/6068 , A61K2039/6081 , A61K2039/627 , C07H15/22 , C12N7/00 , C12N15/1048 , C12N15/1058
摘要： Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
摘要翻译： 本文描述了可用作针对一种或多种人或兽医治疗适应症的疫苗的寡糖 - 寡核苷酸缀合物，以及合成和鉴定它们的方法。 可以使用非人抗体作为结合靶标鉴定缀合物，从而扩大本发明的功能和范围。 有效的缀合物可以通过迭代来鉴定。
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