发明申请
- 专利标题: Anti-Mesothelin Antibodies
- 专利标题(中): 抗间皮素抗体
-
申请号: US12545369申请日: 2009-08-21
-
公开(公告)号: US20100028336A1公开(公告)日: 2010-02-04
- 发明人: Wolfgang Ebel , Luigi Grasso , Nicholas C. Nicolaides , Philip M. Sass , Eric Routhier
- 申请人: Wolfgang Ebel , Luigi Grasso , Nicholas C. Nicolaides , Philip M. Sass , Eric Routhier
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07H21/04 ; A61P35/00 ; C12N15/74 ; C12N5/16
摘要:
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
公开/授权文献
- US08206710B2 Anti-mesothelin antibodies 公开/授权日:2012-06-26