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公开(公告)号：US20140086928A1
公开(公告)日：2014-03-27
申请号：US14091028
申请日：2013-11-26
申请人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
发明人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
IPC分类号： C07K16/24
CPC分类号： C07K16/243 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/63
摘要： Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.
摘要翻译： 提供了分泌具有高结合特异性和生物活性的人单克隆抗体的杂交瘤系，特别是针对粒细胞 - 巨噬细胞集落刺激因子的中和活性，以及产生杂交瘤系的方法。 还提供靶抗原和表位。 抗体可用于治疗方法，例如用于治疗癌症，感染性疾病或自身免疫性疾病。
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公开(公告)号：US20100028336A1
公开(公告)日：2010-02-04
申请号：US12545369
申请日：2009-08-21
IPC分类号： A61K39/395 , C07H21/04 , A61P35/00 , C12N15/74 , C12N5/16
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/732 , C07K2317/77
摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
摘要翻译： 本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。 该抗体可用于特异性递送表达间皮素的药物学药剂，以及引发免疫效应物特异性对肿瘤细胞和前体的活性。 本发明还涉及表达单克隆抗体，多克隆抗体，抗体衍生物如人，人源化和嵌合单克隆抗体的细胞，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用 抗体，衍生物和片段。
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公开(公告)号：US20100008851A1
公开(公告)日：2010-01-14
申请号：US12494631
申请日：2009-06-30
申请人： Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Wolfgang Ebel , Yuhong Zhou , Xun Zuo , Eric Routhier , Jun Yao
发明人： Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Wolfgang Ebel , Yuhong Zhou , Xun Zuo , Eric Routhier , Jun Yao
IPC分类号： A61K51/00 , C07K16/18 , C12N15/11 , A61K39/395 , C12N15/00 , C12N1/21 , C12N5/06 , C12P21/02 , A61K49/00
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US20050054056A1
公开(公告)日：2005-03-10
申请号：US10912922
申请日：2004-08-05
申请人： Wolfgang Ebel , Luigi Grasso , Nicholas Nicolaides , Philip Sass
发明人： Wolfgang Ebel , Luigi Grasso , Nicholas Nicolaides , Philip Sass
CPC分类号： C07K16/30
摘要： The protein and nucleic acid sequences of mesovt2, specific antibodies thereto, methods for targeting and/or inhibiting the growth of cells bearing mesovt2, and methods of use of mesovt2 for diagnosing malignancy are provided. Methods of use of the mesovt2 antibodies in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the mesovt2 antigen, such as pancreatic adenocarcinoma, lung carcinoma, and ovarian cancer, also are provided. The invention also relates to cells expressing the monoclonal antibodies, derivatives, and fragments.
摘要翻译： 提供mesovt2的蛋白质和核酸序列，其特异性抗体，靶向和/或抑制携带mesovt2的细胞生长的方法，以及mesovt2用于诊断恶性肿瘤的方法。 还提供了使用mesovt2抗体治疗某些癌症的方法，特别是已经增加mesovt2抗原例如胰腺癌，肺癌和卵巢癌的细胞表面表达的癌症。 本发明还涉及表达单克隆抗体，衍生物和片段的细胞。
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公开(公告)号：US20120237509A1
公开(公告)日：2012-09-20
申请号：US13476656
申请日：2012-05-21
IPC分类号： A61K39/395 , C12N5/10 , C12N15/63 , C12N15/13 , A61P35/00
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/732 , C07K2317/77
摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
摘要翻译： 本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。 该抗体可用于特异性递送表达间皮素的药物学药剂，以及引发免疫效应物特异性对肿瘤细胞和前体的活性。 本发明还涉及表达单克隆抗体，多克隆抗体，抗体衍生物如人，人源化和嵌合单克隆抗体的细胞，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用 抗体，衍生物和片段。
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6.发明申请公开(公告)号：US20060258007A1
公开(公告)日：2006-11-16
申请号：US11435001
申请日：2006-05-15
申请人： Nicholas Nicolaides , Wolfgang Ebel , Philip Sass , Luigi Grasso
发明人： Nicholas Nicolaides , Wolfgang Ebel , Philip Sass , Luigi Grasso
CPC分类号： C12N15/65 , C12N15/1034 , C12N15/85 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to expression vectors containing nucleic acid sequences encoding one or more proteins of interest linked to one or more selection markers that can be used to select cells null for such vector and to such null cells.
摘要翻译： 本发明涉及包含编码与一种或多种选择标记连锁的一种或多种感兴趣的蛋白质的核酸序列的表达载体，所述选择标记可用于选择对于这种载体无效的细胞和这种无效细胞。
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公开(公告)号：US08623364B2
公开(公告)日：2014-01-07
申请号：US13659165
申请日：2012-10-24
申请人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
发明人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
IPC分类号： A61K39/395 , C07K16/00 , C07K16/22 , C12P21/08
CPC分类号： C07K16/243 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/63
摘要： Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.
摘要翻译： 提供了分泌具有高结合特异性和生物活性的人单克隆抗体的杂交瘤系，特别是针对粒细胞 - 巨噬细胞集落刺激因子的中和活性，以及产生杂交瘤系的方法。 还提供靶抗原和表位。 抗体可用于治疗方法，例如用于治疗癌症，感染性疾病或自身免疫性疾病。
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公开(公告)号：US20130058945A1
公开(公告)日：2013-03-07
申请号：US13659165
申请日：2012-10-24
申请人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
发明人： Philip M. Sass , Nicholas C. Nicolaides , Luigi Grasso , Jian Li , Qimin Chao , Eric Routhier , Wolfgang Ebel
IPC分类号： A61K39/395 , C07K16/24 , C12N5/10 , C12N15/13 , C12N15/85
CPC分类号： C07K16/243 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/63
摘要： Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.
摘要翻译： 提供了分泌具有高结合特异性和生物活性的人单克隆抗体的杂交瘤系，特别是针对粒细胞 - 巨噬细胞集落刺激因子的中和活性，以及产生杂交瘤系的方法。 还提供靶抗原和表位。 抗体可用于治疗方法，例如用于治疗癌症，感染性疾病或自身免疫性疾病。
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公开(公告)号：US20120328524A1
公开(公告)日：2012-12-27
申请号：US13593057
申请日：2012-08-23
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US08206710B2
公开(公告)日：2012-06-26
申请号：US12545369
申请日：2009-08-21
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/732 , C07K2317/77
摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
摘要翻译： 本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。 该抗体可用于特异性递送表达间皮素的药物学药剂，以及引发免疫效应物特异性对肿瘤细胞和前体的活性。 本发明还涉及表达单克隆抗体，多克隆抗体，抗体衍生物如人，人源化和嵌合单克隆抗体的细胞，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用 抗体，衍生物和片段。
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