Invention Application
- Patent Title: Il-17 homologous polypeptides and therapeutic uses thereof
- Patent Title (中): II-17同源多肽及其治疗用途
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Application No.: US12549497Application Date: 2009-08-28
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Publication No.: US20100028343A1Publication Date: 2010-02-04
- Inventor: Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
- Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61P19/02
Abstract:
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Public/Granted literature
- US08034342B2 Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E Public/Granted day:2011-10-11
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