公开(公告)号：US08273703B2

公开(公告)日：2012-09-25

申请号：US11529324

申请日：2006-09-29

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gumey ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gumey ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC分类号： A61K38/16

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US08034342B2

公开(公告)日：2011-10-11

申请号：US12549497

申请日：2009-08-28

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC分类号： A61K39/00 ,  A61K39/395

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20110064728A1

公开(公告)日：2011-03-17

申请号：US12825263

申请日：2010-06-28

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gumey ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： A61K39/395 ,  A61K38/16 ,  A61P1/00 ,  A61P11/06 ,  A61P17/00 ,  A61P19/00

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C07K2319/30 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20080160021A1

公开(公告)日：2008-07-03

申请号：US11949633

申请日：2007-12-03

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William J. Wood ,  Daniel G. Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William J. Wood ,  Daniel G. Yansura

IPC分类号： A61K39/395 ,  A61P19/02

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20060205038A1

公开(公告)日：2006-09-14

申请号：US11436554

申请日：2006-05-19

申请人： Jian Chen ,  Ellen Fivaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William Wood

发明人： Jian Chen ,  Ellen Fivaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William Wood

IPC分类号： C07K14/54 ,  C07H21/04 ,  C12P21/04 ,  C12N15/63

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US20120058909A1

公开(公告)日：2012-03-08

申请号：US13269984

申请日：2011-10-10

申请人： Jian Chen ,  Elleri Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hilian ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

发明人： Jian Chen ,  Elleri Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hilian ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC分类号： C40B30/04 ,  G01N33/574 ,  C12Q1/68

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

公开(公告)号：US07217412B2

公开(公告)日：2007-05-15

申请号：US09854208

申请日：2001-05-10

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K45/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US20060088916A1

公开(公告)日：2006-04-27

申请号：US11311555

申请日：2005-12-20

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

IPC分类号： C07K14/54 ,  C07H21/04 ,  C12P21/06 ,  C07K16/24

CPC分类号： C07K14/54

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20120064073A1

公开(公告)日：2012-03-15

申请号：US13270006

申请日：2011-10-10

申请人： Jian Chen ,  Ellen Fllvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

发明人： Jian Chen ,  Ellen Fllvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC分类号： A61K39/395 ,  A61P19/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P37/08 ,  A61P29/00 ,  A61P1/00

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20090291097A1

公开(公告)日：2009-11-26

申请号：US11802794

申请日：2007-05-25

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P37/00

CPC分类号： C07K14/54 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.