Invention Application
- Patent Title: IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS
- Patent Title (中): IL-17受体抗原结合蛋白
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Application No.: US12443962Application Date: 2007-10-01
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Publication No.: US20100028345A1Publication Date: 2010-02-04
- Inventor: Joel Tocker , Jacques J. Peschon , David Fitzpatrick , James F. Smothers , Christopher Mehlin , Ai Ching Lim
- Applicant: Joel Tocker , Jacques J. Peschon , David Fitzpatrick , James F. Smothers , Christopher Mehlin , Ai Ching Lim
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- International Application: PCT/US2007/021174 WO 20071001
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07H21/00 ; C12N15/63 ; A61P3/00 ; A61P29/00 ; A61P19/02 ; A61P37/06
Abstract:
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.
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