发明申请
US20100029685A1 OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
审中-公开
奥沙利多和噻唑烷酮化合物及其作为NICOTINIC乙酰胆碱受体调节剂
- 专利标题： OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
- 专利标题（中）： 奥沙利多和噻唑烷酮化合物及其作为NICOTINIC乙酰胆碱受体调节剂
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申请号： US12447205申请日： 2007-10-24
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公开(公告)号： US20100029685A1公开(公告)日： 2010-02-04
- 发明人: Bjarne H. Dahl , Dan Peters , Gunnar M. Olsen , Daniel B. Timmermann , Susanne Jorgensen
- 申请人： Bjarne H. Dahl , Dan Peters , Gunnar M. Olsen , Daniel B. Timmermann , Susanne Jorgensen
- 申请人地址： DK Ballerup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200601380 20061025
- 国际申请： PCT/EP2007/061433 WO 20071024
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; C07D271/07 ; C07D401/14 ; C07D285/08 ; C07D413/04 ; C07D417/04 ; A61K31/4439 ; A61K31/4155 ; A61P25/28 ; A61P25/02
摘要：
This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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