发明申请
US20100035960A1 BIOSYNTHETIC PATHWAY AND GENES REQUIRED FOR TROPODITHIETIC ACID BIOSYNTHESIS IN SILICIBACTER TM1040
有权
生物活性途径及其在硅胶TM1040中用于磷酸三钙生物合成的基因
- 专利标题： BIOSYNTHETIC PATHWAY AND GENES REQUIRED FOR TROPODITHIETIC ACID BIOSYNTHESIS IN SILICIBACTER TM1040
- 专利标题（中）： 生物活性途径及其在硅胶TM1040中用于磷酸三钙生物合成的基因
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申请号： US12472296申请日： 2009-05-26
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公开(公告)号： US20100035960A1公开(公告)日： 2010-02-11
- 发明人: Robert Belas , Haifeng Geng , Ryan Powell
- 申请人： Robert Belas , Haifeng Geng , Ryan Powell
- 申请人地址： US MD Baltimore
- 专利权人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
- 当前专利权人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
- 当前专利权人地址： US MD Baltimore
- 主分类号： A61K31/38
- IPC分类号： A61K31/38 ; C07H21/04 ; C07K14/195 ; C07D339/00 ; C12P17/00 ; C12N15/63
摘要：
Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA biosynthesis in roseobacters is described. The TDA produced from roseobacters, specifically Silicibacter sp. TM1040, is shown to have antibacterial activity, in particular against Vibrio anguillarium, Vibrio cholerae, Vibrio coralliilyticus, Vibrio shiloi, Halomonas spp., Mycobacterium marinum, Mycobacterium tuberculosis, Pseudomonas elongate, Spongiobacter nikelotolerans, and Staphylococcus aureus (MRSA).
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