发明申请
- 专利标题： ACTIVATED HER3 AS A MARKER FOR PREDICTING THERAPEUTIC EFFICACY
- 专利标题（中）： 作为预防治疗效果的标记激活
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申请号： US12516682申请日： 2007-11-28
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公开(公告)号： US20100047829A1公开(公告)日： 2010-02-25
- 发明人: Mike Rothe , Martin Treder
- 申请人： Mike Rothe , Martin Treder
- 申请人地址： DE Martinsried
- 专利权人： U3 PHARMA GMBH
- 当前专利权人： U3 PHARMA GMBH
- 当前专利权人地址： DE Martinsried
- 优先权： EP06024658.4 20061128
- 国际申请： PCT/EP2007/010335 WO 20071128
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K16/00
摘要：
The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment, utilizing a tissue sample from a test subject, for example tumor material or normal tissue such as skin or hair follicle. Further, methods for the treatment of HER receptor-associated diseases are disclosed.
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