发明申请
- 专利标题: Pharmaceutical Formulation Comprising Donepezil
- 专利标题(中): 药物制剂包含多奈哌齐
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申请号: US12374786申请日: 2007-06-29
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公开(公告)号: US20100055171A1公开(公告)日: 2010-03-04
- 发明人: Violeta Cindric , Ivica Grebenar , Snjezana Miric , Maja Devcic
- 申请人: Violeta Cindric , Ivica Grebenar , Snjezana Miric , Maja Devcic
- 申请人地址: HR Zagreb
- 专利权人: PLIVA Hrvatska d.o.o.
- 当前专利权人: PLIVA Hrvatska d.o.o.
- 当前专利权人地址: HR Zagreb
- 优先权: GB0614586.6 20060722
- 国际申请: PCT/GB2007/002452 WO 20070629
- 主分类号: A61K9/48
- IPC分类号: A61K9/48 ; A61K31/445 ; A61K9/28
摘要:
The present invention relates to a pharmaceutical composition comprising 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one, herein after referred to as Donepezil, or a pharmaceutically acceptable salt thereof, for treating of Alzheimer's disease and senile dementia. The present invention also relates to a manufacturing process for the preparation of Donepezil tablets containing and retaining polymorphic Form I of Donepezil hydrochloride. This composition also discloses the use of the excipients that ensure adequate flowability of a dry blend as well as required content uniformity and drug release rate of the final product.