发明申请
US20100069372A1 COMPOSITIONS AND METHODS FOR MODULATING POLY(ADP-RIBOSE) POLYMERASE ACTIVITY
审中-公开
用于调节聚（ADP-RIBOSE）聚合酶活性的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR MODULATING POLY(ADP-RIBOSE) POLYMERASE ACTIVITY
- 专利标题（中）： 用于调节聚（ADP-RIBOSE）聚合酶活性的组合物和方法
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申请号： US12559036申请日： 2009-09-14
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公开(公告)号： US20100069372A1公开(公告)日： 2010-03-18
- 发明人: Aleksey G. Kazantsev
- 申请人： Aleksey G. Kazantsev
- 申请人地址： US MA Boston
- 专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： US MA Boston
- 主分类号： A61K31/5513
- IPC分类号： A61K31/5513 ; A61P25/00 ; A61P25/16 ; A61P25/28
摘要：
The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP-1 activity).
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