利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.022 秒)

    Compositions and methods for modulating sirtuin activity
    3.
    发明申请
    Compositions and methods for modulating sirtuin activity 审中-公开
    调节sirtuin活性的组合物和方法

    公开(公告)号：US20090069559A1

    公开(公告)日：2009-03-12

    申请号：US12100080

    申请日：2008-04-09

    申请人： Aleksey G. Kazantsev

    发明人： Aleksey G. Kazantsev

    IPC分类号： C07D401/12 ,  C07D401/10 ,  C07D413/10

    CPC分类号： C07D405/12 ,  C07D295/26 ,  C07D401/12

    摘要： The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).

    摘要翻译： 本发明部分基于我们发现抑制沉默调节蛋白的活性的化合物（例如，抑制或优先抑制SIRT2活性的化合物），因此被认为可用于治疗或预防与sirtuin相关的疾病 活动。 这些疾病包括但不限于神经障碍如帕金森病（PD）。

    COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY 有权
    用于调节SIRTUIN活性的组合物和方法

    公开(公告)号：US20090259044A1

    公开(公告)日：2009-10-15

    申请号：US12143478

    申请日：2008-06-20

    申请人： Aleksey G. Kazantsev

    发明人： Aleksey G. Kazantsev

    IPC分类号： C07D215/38

    CPC分类号： C07D401/12 ,  C07D405/12

    摘要： The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).

    摘要翻译： 本发明部分基于我们发现抑制沉默调节蛋白的活性的化合物（例如，抑制或优先抑制SIRT2活性的化合物），因此被认为可用于治疗或预防与sirtuin相关的疾病 活动。 这些疾病包括但不限于神经障碍如帕金森病（PD）。

    Compositions and methods for modulating sirtuin activity
    5.
    发明授权
    Compositions and methods for modulating sirtuin activity 有权
    调节sirtuin活性的组合物和方法

    公开(公告)号：US08153803B2

    公开(公告)日：2012-04-10

    申请号：US12143478

    申请日：2008-06-20

    申请人： Aleksey G. Kazantsev

    发明人： Aleksey G. Kazantsev

    IPC分类号： C07D215/38

    CPC分类号： C07D401/12 ,  C07D405/12

    摘要： The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).

    摘要翻译： 本发明部分基于我们发现抑制沉默调节蛋白的活性的化合物（例如，抑制或优先抑制SIRT2活性的化合物），因此被认为可用于治疗或预防与sirtuin相关的疾病 活动。 这些疾病包括但不限于神经障碍如帕金森病（PD）。

    Compositions and methods for modulating sirtuin activity
    6.
    发明申请
    Compositions and methods for modulating sirtuin activity 审中-公开
    调节sirtuin活性的组合物和方法

    公开(公告)号：US20080021063A1

    公开(公告)日：2008-01-24

    申请号：US11488293

    申请日：2006-07-18

    申请人： Aleksey G. Kazantsev

    发明人： Aleksey G. Kazantsev

    IPC分类号： A61K31/47 ,  C07D215/00 ,  C07D215/38

    CPC分类号： C07D405/12 ,  C07D295/26 ,  C07D401/12

    摘要： The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).

    摘要翻译： 本发明部分基于我们发现抑制沉默调节蛋白的活性的化合物（例如，抑制或优先抑制SIRT2活性的化合物），因此被认为可用于治疗或预防与sirtuin相关的疾病 活动。 这些疾病包括但不限于神经障碍如帕金森病（PD）。

    Methods of identifying agents that mediate polypeptide aggregation
    9.
    发明授权
    Methods of identifying agents that mediate polypeptide aggregation 失效
    鉴定介导多肽聚集的试剂的方法

    公开(公告)号：US07015012B2

    公开(公告)日：2006-03-21

    申请号：US10470765

    申请日：2002-02-11

    申请人： David E. Housman ,  Aleksey G. Kazantsev

    发明人： David E. Housman ,  Aleksey G. Kazantsev

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/5058 ,  A61K31/18 ,  A61K31/215 ,  A61K31/235 ,  A61K31/428 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/582 ,  G01N33/6803 ,  G01N33/6896 ,  G01N2500/02

    摘要： The present invention is based, in part, on the discovery of methods for identifying compounds that mediate (by promoting or inhibiting) protein-protein interaction (e.g., aggregation, dimerization, or other physiologically significant association). Compounds that mediate such interaction, which are also within the scope of the invention, can be used to treat Alzheimer's disease, disorders associated with expanded CAG repeats (such as Huntington's disease), and disorders in which polyglutamine-containing transcription factors or coactivators are undesirably active (e.g., disorders associated with homodimerization of jun or hexamerization of p53.

    摘要翻译： 本发明部分地基于用于鉴定介导（通过促进或抑制）蛋白质 - 蛋白质相互作用（例如，聚集，二聚化或其它生理学显着关联）的化合物的方法的发现。 介导这种相互作用的化合物，其也在本发明的范围内，可用于治疗阿尔茨海默病，与扩大的CAG重复（例如亨廷顿病）相关的病症，以及其中含有多聚谷氨酰胺的转录因子或共激活因子是不期望的疾病 活性（例如，与p53的jun或hexamerization的同二聚化相关的障碍。