Embodiments of the invention may provide for a frequency synthesizer capable to generate an output signal in which the frequency is a fractional portion of the reference frequency without a fractional divider. Based on mathematical relationship (“relatively prime”) between the reference frequency and other injection frequencies mixed with the output signal of a voltage controlled oscillator, the synthesizer is able to generate signals evenly spaced in the frequency domain like Fractional-N PLLs. The synthesizer may include an Integer-N PLL, a SSB mixer, frequency dividers, and frequency multipliers. A Integer-N PLL may include a Phase and Frequency Detector, a Charge Pump, a Loop Filter and a Dual Modulus Divider. By not requiring a fractional divider, the frequency synthesizer is able to avoid adopting any compensation circuits such as Sigma-Delta modulator to suppress fractional spurs. Therefore, the chip area, power consumption and complexity will be reduced considerably.