发明申请
- 专利标题: TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES
- 专利标题(中): 三聚吲哚和(4,5-二羟基)吲哚
-
申请号: US12516712申请日: 2007-11-23
-
公开(公告)号: US20100075998A1公开(公告)日: 2010-03-25
- 发明人: Ermes Vanotti , Marina Caldarelli , Francesco Casuscelli , Barbara Forte , Maria Menichincheri , Alessandra Scolaro , Gabriella Traquandi , Paola Vianello
- 申请人: Ermes Vanotti , Marina Caldarelli , Francesco Casuscelli , Barbara Forte , Maria Menichincheri , Alessandra Scolaro , Gabriella Traquandi , Paola Vianello
- 申请人地址: IT Nerviano (MI)
- 专利权人: NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人: NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人地址: IT Nerviano (MI)
- 优先权: EP06124947.0 20061128
- 国际申请: PCT/EP07/62762 WO 20071123
- 主分类号: A61K31/4162
- IPC分类号: A61K31/4162 ; C12N9/99 ; A61K31/519 ; A61K31/437 ; C07D471/04 ; C07D487/04 ; A61P35/00
摘要:
The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, means either simple or double carbon-carbon bond and R1, R2 and R3 are as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.
公开/授权文献
- US08207180B2 Tricyclic indoles and (4,5-dihydro) indoles 公开/授权日:2012-06-26
信息查询
IPC分类: