发明申请
US20100076003A1 5-OXAZOLIDIN-2-ONE SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS
审中-公开
5-OZAZOLIDIN-2-ONE替代1,3,8-三唑基[4.5]十二烷-4-酮衍生物作为ORL-1受体调节剂有用
![5-OXAZOLIDIN-2-ONE SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS](/docs/US/2010-03-25/US20100076003A1/abs.jpg.600x600.jpg)
- 专利标题： 5-OXAZOLIDIN-2-ONE SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS
- 专利标题（中）： 5-OZAZOLIDIN-2-ONE替代1,3,8-三唑基[4.5]十二烷-4-酮衍生物作为ORL-1受体调节剂有用
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申请号： US12479103申请日： 2009-06-05
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公开(公告)号： US20100076003A1公开(公告)日： 2010-03-25
- 发明人: Kathleen BATTISTA , Gilles Bignan , Peter J. Connolly , Tina Morgan Ross
- 申请人： Kathleen BATTISTA , Gilles Bignan , Peter J. Connolly , Tina Morgan Ross
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D471/10
![5-OXAZOLIDIN-2-ONE SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS](/abs-image/US/2010/03/25/US20100076003A1/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to novel 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful in the treatment of disorders and conditions mediated by the ORL-1 receptor. The present invention is further directed to processes for the preparation of said derivatives, pharmaceutical compositions comprising said derivatives and methods for the treatment of ORL-1 mediated disorders and conditions.