Invention Application
- Patent Title: NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL DRUGS
- Patent Title (中): 新型含氮杂环化合物,其制备及其作为抗菌药物使用
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Application No.: US12536096Application Date: 2009-08-05
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Publication No.: US20100087648A1Publication Date: 2010-04-08
- Inventor: Maxime Lampilas , David Rowlands , Benoit Ledoussal , Marie-Edith Gourdel , Emilie Renaud , Camille Pierres , Adel Kebsi
- Applicant: Maxime Lampilas , David Rowlands , Benoit Ledoussal , Marie-Edith Gourdel , Emilie Renaud , Camille Pierres , Adel Kebsi
- Applicant Address: FR Romainville
- Assignee: Novexel
- Current Assignee: Novexel
- Current Assignee Address: FR Romainville
- Priority: FR0805472 20081003
- Main IPC: C07D471/06
- IPC: C07D471/06

Abstract:
The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their preparation and to their use as antibacterial drugs.
Public/Granted literature
- US08067435B2 Nitrogen-containing heterocyclic compounds, their preparation and their use as antibacterial drugs Public/Granted day:2011-11-29
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