发明申请
US20100093085A1 TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE
有权
三聚寡核苷酸复合物和通过RNA干扰进行基因沉默的方法
- 专利标题： TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE
- 专利标题（中）： 三聚寡核苷酸复合物和通过RNA干扰进行基因沉默的方法
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申请号： US12442278申请日： 2007-09-20
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公开(公告)号： US20100093085A1公开(公告)日： 2010-04-15
- 发明人: Christina Yamada , Anastasia Khvorova , Rob Kaiser , Emily Anderson , Devin Leake
- 申请人： Christina Yamada , Anastasia Khvorova , Rob Kaiser , Emily Anderson , Devin Leake
- 申请人地址： US CO LAFAYETTE
- 专利权人： DHARMACON, INC
- 当前专利权人： DHARMACON, INC
- 当前专利权人地址： US CO LAFAYETTE
- 国际申请： PCT/US07/79074 WO 20070920
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C07H21/04
摘要：
Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene. The tripartite oligonucleotide complexes of the disclosure may include a conjugate moiety that facilitates delivery to a cell, tissue or organism without the aid of a transfection reagent