发明申请
- 专利标题： METHODS FOR JOINT LUBRICATION AND CARTILAGE WEAR PREVENTION MAKING USE OF GLYCEROPHOSPHOLIPIDS
- 专利标题（中）： 联合润滑和卡片预防方法使用甘油磷脂
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申请号： US12411855申请日： 2009-03-26
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公开(公告)号： US20100098749A1公开(公告)日： 2010-04-22
- 发明人: Yechezkel BARENHOLZ , Dorit NITZAN , Izhak ETSION , Avi SCHROEDER , Grigory HALPERIN , Sarit SIVAN
- 申请人： Yechezkel BARENHOLZ , Dorit NITZAN , Izhak ETSION , Avi SCHROEDER , Grigory HALPERIN , Sarit SIVAN
- 申请人地址： IL Jerusalem IL Haifa IL Jerusalem
- 专利权人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED,TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
- 当前专利权人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED,TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
- 当前专利权人地址： IL Jerusalem IL Haifa IL Jerusalem
- 主分类号： A61K9/127
- IPC分类号： A61K9/127
摘要：
The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C15 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints.