公开(公告)号：US20100098749A1

公开(公告)日：2010-04-22

申请号：US12411855

申请日：2009-03-26

申请人： Yechezkel BARENHOLZ ,  Dorit NITZAN ,  Izhak ETSION ,  Avi SCHROEDER ,  Grigory HALPERIN ,  Sarit SIVAN

发明人： Yechezkel BARENHOLZ ,  Dorit NITZAN ,  Izhak ETSION ,  Avi SCHROEDER ,  Grigory HALPERIN ,  Sarit SIVAN

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/685 ,  A61L27/50 ,  A61L2430/24

摘要： The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C15 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints.

摘要翻译： 本发明涉及联合润滑和/或预防软骨磨损的方法，其使用具有至少一种磷脂（PL）的脂质体的脂质体，所述磷脂由具有两个相同或不同的C12-脂肪酸的甘油磷脂（GPL）组成， C16烃链和具有C12-C18烃链的鞘脂（SPL），所述一种或多种膜具有其中发生固体有序（SO）至液体无序（LD）相变的相变温度，相转变温度在 温度为约20℃至约39℃，用于润滑接头。

公开(公告)号：US08895054B2

公开(公告)日：2014-11-25

申请号：US12411855

申请日：2009-03-26

申请人： Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

发明人： Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K31/685 ,  A61L27/50

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/685 ,  A61L27/50 ,  A61L2430/24

摘要： The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C15 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints.

摘要翻译： 本发明涉及联合润滑和/或预防软骨磨损的方法，其使用具有至少一种磷脂（PL）的脂质体的脂质体，所述磷脂由具有两个相同或不同的C12-脂肪酸的甘油磷脂（GPL）组成， C16烃链和具有C12-C18烃链的鞘脂（SPL），所述一种或多种膜具有其中发生固体有序（SO）至液体无序（LD）相变的相变温度，相转变温度在 温度为约20℃至约39℃，用于润滑接头。