发明申请
US20100112607A1 METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION)
有权
使用可释放的PEG试剂（在体外去PEG化）中测定丙型肝素PEG蛋白质结合物中活性成分的方法
- 专利标题： METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION)
- 专利标题（中）： 使用可释放的PEG试剂（在体外去PEG化）中测定丙型肝素PEG蛋白质结合物中活性成分的方法
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申请号： US12582497申请日： 2009-10-20
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公开(公告)号： US20100112607A1公开(公告)日： 2010-05-06
- 发明人: Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
- 申请人： Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
- 申请人地址： US IL Deerfield CH Glattpark ( Opfikon) US CA San Carlos
- 专利权人： BAXTER INTERNATIONAL INC.,BAXTER HEALTHCARE S.A.,NEKTAR THERAPEUTICS
- 当前专利权人： BAXTER INTERNATIONAL INC.,BAXTER HEALTHCARE S.A.,NEKTAR THERAPEUTICS
- 当前专利权人地址： US IL Deerfield CH Glattpark ( Opfikon) US CA San Carlos
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K14/00
摘要：
The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
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