发明申请
- 专利标题: (PYRROLIDIN-2-YL)PHENYL DERIVATIVES
- 专利标题(中): (吡咯烷-2-基)苯基衍生物
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申请号: US12611468申请日: 2009-11-03
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公开(公告)号: US20100113493A1公开(公告)日: 2010-05-06
- 发明人: Simon James Anthony Grove , Ronald Palin , Ashvinkumar Dhirubhai Mistry , John Kinnaird Ferguson MacLean
- 申请人: Simon James Anthony Grove , Ronald Palin , Ashvinkumar Dhirubhai Mistry , John Kinnaird Ferguson MacLean
- 专利权人: N.V. Organon
- 当前专利权人: N.V. Organon
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; C07D401/10 ; A61P29/00 ; A61P25/00
摘要:
The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.
公开/授权文献
- US08188123B2 (Pyrrolidin-2-yl)phenyl derivatives 公开/授权日:2012-05-29
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