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    (Pyrrolidin-2-yl)phenyl derivatives
    1.
    发明授权
    (Pyrrolidin-2-yl)phenyl derivatives 有权
    （吡咯烷-2-基）苯基衍生物

    公开(公告)号：US08188123B2

    公开(公告)日：2012-05-29

    申请号：US12611468

    申请日：2009-11-03

    申请人： Simon James Anthony Grove ,  Ronald Palin ,  Ashvinkumar Dhirubhai Mistry ,  John Kinnaird Ferguson MacLean

    发明人： Simon James Anthony Grove ,  Ronald Palin ,  Ashvinkumar Dhirubhai Mistry ,  John Kinnaird Ferguson MacLean

    IPC分类号： A61K31/4439 ,  C07D401/10

    CPC分类号： C07D401/10

    摘要： The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

    摘要翻译： 本发明涉及具有通式I的（吡咯烷-2-基）苯基衍生物，其中R 1是（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基或卤代（C 1-4） 烷氧基 R 2是H，（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基，卤代（C 1-4）烷氧基或卤素; R3是H，（C1-4）烷基或卤代（C1-4）烷基; R4是H，（C1-4）烷基或卤代（C1-4）烷基; R5是H，（C1-4）烷基或卤代（C1-4） - 烷基; 或R 4和R 5在与相同碳原子键合时可与碳原子一起形成任选被卤素取代的螺（C 3-6）环烷基; R 6为H，（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基，卤代（C 1-4）烷氧基或卤素; 或其药学上可接受的盐，包含其的药物组合物，以及这些（吡咯烷-2-基）苯基衍生物用于治疗疼痛如神经性疼痛或炎性疼痛的用途。

    (PYRROLIDIN-2-YL)PHENYL DERIVATIVES
    2.
    发明申请
    (PYRROLIDIN-2-YL)PHENYL DERIVATIVES 有权
    （吡咯烷-2-基）苯基衍生物

    公开(公告)号：US20100113493A1

    公开(公告)日：2010-05-06

    申请号：US12611468

    申请日：2009-11-03

    申请人： Simon James Anthony Grove ,  Ronald Palin ,  Ashvinkumar Dhirubhai Mistry ,  John Kinnaird Ferguson MacLean

    发明人： Simon James Anthony Grove ,  Ronald Palin ,  Ashvinkumar Dhirubhai Mistry ,  John Kinnaird Ferguson MacLean

    IPC分类号： A61K31/4439 ,  C07D401/10 ,  A61P29/00 ,  A61P25/00

    CPC分类号： C07D401/10

    摘要： The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; R3 is H, (C1-4)alkyl or halo(C1-4)alkyl; R4 is H, (C1-4)alkyl or halo(C1-4)alkyl; R5 is H, (C1-4)alkyl or halo-(C1-4)-alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C3-6)cycloalkyl group, optionally substituted with halogen; R6 is H, (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, halo(C1-4)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

    摘要翻译： 本发明涉及具有通式I的（吡咯烷-2-基）苯基衍生物，其中R 1是（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基或卤代（C 1-4） 烷氧基 R 2是H，（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基，卤代（C 1-4）烷氧基或卤素; R3是H，（C1-4）烷基或卤代（C1-4）烷基; R4是H，（C1-4）烷基或卤代（C1-4）烷基; R5是H，（C1-4）烷基或卤代（C1-4） - 烷基; 或R 4和R 5在与相同碳原子键合时可与碳原子一起形成任选被卤素取代的螺（C 3-6）环烷基; R 6为H，（C 1-4）烷基，卤代（C 1-4）烷基，（C 1-4）烷氧基，卤代（C 1-4）烷氧基或卤素; 或其药学上可接受的盐，包含其的药物组合物，以及这些（吡咯烷-2-基）苯基衍生物用于治疗疼痛如神经性疼痛或炎性疼痛的用途。