发明申请
US20100113498A1 NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES
失效
新型VINBLASTINE衍生物，其制备，使用和药物组合物，包含该衍生物
- 专利标题： NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES
- 专利标题（中）： 新型VINBLASTINE衍生物，其制备，使用和药物组合物，包含该衍生物
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申请号： US12449180申请日： 2007-12-17
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公开(公告)号： US20100113498A1公开(公告)日： 2010-05-06
- 发明人: Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou
- 申请人： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou
- 申请人地址： CN Pudong, Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Pudong, Shanghai
- 优先权： CN200710036923.2 20070129
- 国际申请： PCT/CN2007/003624 WO 20071217
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D461/00 ; A61P35/00
摘要：
The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
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