发明申请
US20100125127A1 B7-related nucleic acids and polypeptides useful for immunomodulation
有权
B7相关的核酸和可用于免疫调节的多肽
- 专利标题： B7-related nucleic acids and polypeptides useful for immunomodulation
- 专利标题（中）： B7相关的核酸和可用于免疫调节的多肽
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申请号： US12069064申请日： 2008-02-07
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公开(公告)号： US20100125127A1公开(公告)日： 2010-05-20
- 发明人: Glen E. Mikesell , Henry Shen , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach
- 申请人： Glen E. Mikesell , Henry Shen , Han Chang , Joshua N. Finger , Guchen Yang , Robert James Peach
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K7/08 ; C07K5/06 ; C07K5/08 ; C07K5/10 ; C07K14/00 ; C07K16/00 ; C07C211/00
摘要：
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
公开/授权文献
- US07807786B2 BSL2v1c2 polypeptides 公开/授权日：2010-10-05
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