Invention Application
- Patent Title: INHIBITORS OF KINASE ACTIVITY
- Patent Title (中): 激酶活性抑制剂
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Application No.: US12515250Application Date: 2007-11-15
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Publication No.: US20100130447A1Publication Date: 2010-05-27
- Inventor: Christopher John Burns , Michael Francis Harte , James T. Palmer
- Applicant: Christopher John Burns , Michael Francis Harte , James T. Palmer
- Priority: AU2006906359 20061115
- International Application: PCT/AU2007/001761 WO 20071115
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D403/12 ; C07F9/09 ; C07D241/26 ; A61K31/5377 ; A61K31/675 ; A61P29/00 ; A61P35/00 ; A61P13/00 ; A61P19/00 ; A61P3/00 ; A61P7/00 ; C12N9/99
Abstract:
The present invention relates to pyridines or pyrazines that inhibit kinases. In particular the compounds of the invention inhibit members of the class III PTK receptor family such as FMS (CSF-IR), c-KIT, PDGFRβ, PDGFRα or FLT3 and KDR, SRC, EphA2, EphA3, EphA8, FLT1, FLT4, HCK, LCK, PTK5 (FRK), SYK, DDR1 and DDR2 and RET. The compounds of the invention are useful in the treatment of kinase associated diseases such as immunological and inflammatory diseases; hyperproliferative diseases including cancer and diseases involving neo-angiogenesis; renal and kidney diseases; bone remodeling diseases; metabolic diseases; and vascular diseases.
Public/Granted literature
- US08461161B2 Substituted pyrazines as inhibitors of kinase activity Public/Granted day:2013-06-11
Information query
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