发明申请
- 专利标题： INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
- 专利标题（中）： 将碳酰胺作为IKK2抑制剂
-
申请号： US12532773申请日： 2008-03-20
-
公开(公告)号： US20100130468A1公开(公告)日： 2010-05-27
- 发明人: Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
- 申请人： Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
- 国际申请： PCT/US08/57583 WO 20080320
- 主分类号： A61K31/405
- IPC分类号： A61K31/405 ; C07D209/04 ; C07D409/14 ; A61K31/55 ; C07D403/02 ; A61K31/497 ; C07D413/02 ; A61K31/535
摘要：
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein.The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
公开/授权文献
- US08071584B2 Indole carboxamides as IKK2 inhibitors 公开/授权日：2011-12-06
信息查询
IPC分类:
