发明申请
- 专利标题： POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF
- 专利标题（中）： 多巴酚丁醚泵抑制剂及其治疗用途
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申请号： US12613329申请日： 2009-11-05
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公开(公告)号： US20100152098A1公开(公告)日： 2010-06-17
- 发明人: Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
- 申请人： Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
- 申请人地址： US CA San Diego
- 专利权人： Mpex Pharmaceuticals, Inc.
- 当前专利权人： Mpex Pharmaceuticals, Inc.
- 当前专利权人地址： US CA San Diego
- 主分类号： A61K38/05
- IPC分类号： A61K38/05 ; A61K38/02 ; C07D265/30 ; C07D241/42 ; C07D215/38 ; C07D211/58 ; C07D211/06 ; C07D213/643 ; C07D213/74 ; C07D231/12 ; C07D209/20 ; C07D207/14 ; C07D333/24 ; C07D321/10 ; C07D319/18 ; C07D309/10 ; C07D307/79 ; C07C311/46 ; C07C237/20 ; A61P31/08 ; A61P31/06 ; A61P31/04 ; C07D217/22 ; A61K31/472
摘要：
Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
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