-
公开(公告)号：US20100152098A1
公开(公告)日：2010-06-17
申请号：US12613329
申请日：2009-11-05
申请人： Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
发明人： Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
IPC分类号： A61K38/05 , A61K38/02 , C07D265/30 , C07D241/42 , C07D215/38 , C07D211/58 , C07D211/06 , C07D213/643 , C07D213/74 , C07D231/12 , C07D209/20 , C07D207/14 , C07D333/24 , C07D321/10 , C07D319/18 , C07D309/10 , C07D307/79 , C07C311/46 , C07C237/20 , A61P31/08 , A61P31/06 , A61P31/04 , C07D217/22 , A61K31/472
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/06104 , C07K5/06113 , C07K5/06139 , C07K5/06191 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
摘要翻译： 公开了具有多碱性官能团的化合物。 该化合物抑制细菌外排泵抑制剂，并与抗菌剂组合使用以治疗或预防细菌感染。 这些组合可以有效地抵抗通过外排泵机制对抗细菌剂产生抗性的细菌感染。
-
2.发明授权公开(公告)号：US08178490B2
公开(公告)日：2012-05-15
申请号：US12613329
申请日：2009-11-05
申请人： Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
发明人： Tomasz Glinka , Olga Rodny , Keith A. Bostian , David M. Wallace , Robert I. Higuchi , Chun Chow , Chi Ching Mak , Gavin Hirst , Brian Eastman
IPC分类号： A61K38/00
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/06104 , C07K5/06113 , C07K5/06139 , C07K5/06191 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
摘要翻译： 公开了具有多碱性官能团的化合物。 该化合物抑制细菌外排泵抑制剂，并与抗菌剂组合使用以治疗或预防细菌感染。 这些组合可以有效地抵抗通过外排泵机制对抗细菌剂产生抗性的细菌感染。
-
公开(公告)号：US08357696B2
公开(公告)日：2013-01-22
申请号：US12695981
申请日：2010-01-28
IPC分类号： A61K9/14 , A61K31/00 , A61K31/44 , A61K31/4412 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A01N25/00 , A01N25/02 , A01N25/06 , A01N59/08
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
-
公开(公告)号：US20100087416A1
公开(公告)日：2010-04-08
申请号：US12574680
申请日：2009-10-06
IPC分类号： A61K31/397 , A61K31/535 , A61P11/06 , A61P11/00
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0078 , A61K31/4375 , A61K31/47 , A61K31/536 , A61K31/538 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
摘要翻译： 本发明涉及抗微生物剂领域。 特别地，本发明涉及用二价或三价阳离子配制的雾化氟喹诺酮类药物，并且具有改善的肺可用性，用于治疗和管理肺和上呼吸道的细菌感染。
-
公开(公告)号：US08815838B2
公开(公告)日：2014-08-26
申请号：US12574680
申请日：2009-10-06
IPC分类号： A61K31/397 , A61K31/535 , A61P11/06 , A61K31/47 , A61K47/02 , A61K31/4375 , A61K31/538 , A61K9/00
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0078 , A61K31/4375 , A61K31/47 , A61K31/536 , A61K31/538 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
摘要翻译： 本发明涉及抗微生物剂领域。 特别地，本发明涉及用二价或三价阳离子配制的雾化氟喹诺酮类药物，并且具有改善的肺可用性，用于治疗和管理肺和上呼吸道的细菌感染。
-
公开(公告)号：US20100158957A1
公开(公告)日：2010-06-24
申请号：US12695981
申请日：2010-01-28
IPC分类号： A61K9/00 , A61K31/5383 , A61K31/496 , A61K31/4375 , A61P31/04
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
-
公开(公告)号：US20100037890A1
公开(公告)日：2010-02-18
申请号：US12604347
申请日：2009-10-22
申请人： Mark W. Surber , Keith A. Bostian , Michael N. Dudley , Olga Lomovskaya (AKA Olga Rodny) , David C. Griffith
发明人： Mark W. Surber , Keith A. Bostian , Michael N. Dudley , Olga Lomovskaya (AKA Olga Rodny) , David C. Griffith
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
摘要翻译： 本文公开了适用于气雾化和使用这种制剂的氟喹诺酮类制剂用于气雾剂施用氟喹诺酮抗微生物剂以治疗肺细菌感染。 特别地，描述了专门配制并递送用于肺细菌感染的吸入性左氧氟沙星。 方法包括用于生产和使用所述组合物的吸入方案和制造方法。
-
公开(公告)号：US08546423B2
公开(公告)日：2013-10-01
申请号：US12604340
申请日：2009-10-22
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4412 , A61K33/00 , A61K33/14 , A61K33/26 , A61K33/30 , A01N25/00 , A01N25/02 , A01N25/06 , A01N59/08
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
-
公开(公告)号：US08524735B2
公开(公告)日：2013-09-03
申请号：US12604347
申请日：2009-10-22
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4412 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A01N25/00 , A01N25/02 , A01N25/06 , A01N59/08
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
摘要翻译： 本文公开了适用于气雾化和使用这种制剂的氟喹诺酮类制剂用于气雾剂施用氟喹诺酮抗微生物剂以治疗肺细菌感染。 特别地，描述了专门配制并递送用于肺细菌感染的吸入性左氧氟沙星。 方法包括用于生产和使用所述组合物的吸入方案和制造方法。
-
公开(公告)号：US20100166673A1
公开(公告)日：2010-07-01
申请号：US12604340
申请日：2009-10-22
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.059 秒)
