发明申请
- 专利标题： CRYSTALLINE FORMS OF ATORVASTATIN 4-(NITROOXY) BUTYL ESTER
- 专利标题（中）： 4-（硝基）丁酯酯的结晶形式
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申请号： US12594511申请日： 2008-03-19
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公开(公告)号： US20100152274A1公开(公告)日： 2010-06-17
- 发明人: Francesca Benedini , Stefano Biondi , Annalisa Bonfanti , Fabio Nicoli
- 申请人： Francesca Benedini , Stefano Biondi , Annalisa Bonfanti , Fabio Nicoli
- 申请人地址： FR Sophia Antipolis- Valbonne
- 专利权人： Nicox S.A.
- 当前专利权人： Nicox S.A.
- 当前专利权人地址： FR Sophia Antipolis- Valbonne
- 国际申请： PCT/EP08/53269 WO 20080319
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; C07D207/327 ; A61P9/00 ; A61P29/00 ; A61P7/02 ; A61P25/00 ; A61P25/28 ; A61P25/16
摘要：
The present invention relates to two crystalline forms designated as form A and form B, of (βR,δR)-2(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbon-yl]-1H-pyrrole-1-heptanoic acid 4-(nitrooxy)butyl ester (atorvastatin 4-(nitrooxy)butyl ester), represented by the formula (I), The invention also relates to processes for the preparation of the forms A and B, to pharmaceutical compositions comprising the two forms, and to their use for treating and/or preventing acute coronary syndromes, stroke, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.
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