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公开(公告)号：US20100152274A1
公开(公告)日：2010-06-17
申请号：US12594511
申请日：2008-03-19
IPC分类号： A61K31/40 , C07D207/327 , A61P9/00 , A61P29/00 , A61P7/02 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D207/34
摘要： The present invention relates to two crystalline forms designated as form A and form B, of (βR,δR)-2(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbon-yl]-1H-pyrrole-1-heptanoic acid 4-(nitrooxy)butyl ester (atorvastatin 4-(nitrooxy)butyl ester), represented by the formula (I), The invention also relates to processes for the preparation of the forms A and B, to pharmaceutical compositions comprising the two forms, and to their use for treating and/or preventing acute coronary syndromes, stroke, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.
摘要翻译： 本发明涉及两种结晶形式，其命名为（＆bgr; R，δR）-2（4-氟苯基） - ，b-，δ-二羟基-5-（1-甲基乙基）-3-苯基的形式A和形式B -4 - [（苯基氨基）碳基] -1H-吡咯-1-庚酸4-（硝基氧基）丁酯（阿托伐他汀4-（硝基氧基）丁酯），由式（I）表示，本发明还涉及 用于制备形式A和B的方法，包含两种形式的药物组合物及其用于治疗和/或预防急性冠状动脉综合征，中风，神经变性疾病如阿尔茨海默病和帕金森病以及自身免疫疾病的用途 ，如多发性硬化症。
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2.发明申请GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY 有权通过位置21中的芳香链接蛋白连接到硝酸盐的葡萄糖结合蛋白及其在眼科学中的应用公开(公告)号：US20110144073A1
公开(公告)日：2011-06-16
申请号：US13056921
申请日：2009-07-07
申请人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
发明人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
CPC分类号： C07J71/0031 , C07J41/005
摘要： The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
摘要翻译： 本发明涉及氟轻松，丙酸钠，倍他米松和倍氯米松的硝基氧基衍生物，其制备方法，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗糖尿病性黄斑水肿，糖尿病性视网膜病变，黄斑变性， 黄斑变性等视网膜黄斑病变。
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公开(公告)号：US08518920B2
公开(公告)日：2013-08-27
申请号：US13056921
申请日：2009-07-07
申请人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
发明人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
IPC分类号： A61K31/58 , A61K31/573 , C07J5/00 , C07J71/00
CPC分类号： C07J71/0031 , C07J41/005
摘要： The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
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