The invention provides a medical device delivery system comprising an offset coupling region interposed between an elongated hypotube guide member or catheter and a support segment. The medical device to be delivered is disposed about the support segment and contained and/or constrained within a containment element. The medical device may be released from the containment element by moving an actuation element from a first position to a second position. The offset coupling region allows the actuation element to exit a lumen within the guide member and to engage the containment element in the first position while traveling along a line generally coaxial with the lumen of the guide member.