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    Embolic filter delivery system and method
    1.
    发明授权
    Embolic filter delivery system and method 有权
    栓塞过滤器输送系统及方法

    公开(公告)号：US08444669B2

    公开(公告)日：2013-05-21

    申请号：US12563758

    申请日：2009-09-21

    Applicant: Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eddie Sucgang

    Inventor： Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eddie Sucgang

    IPC: A61F2/01

    CPC classification number: A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0048

    Abstract: The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.

    Abstract translation: 本公开涉及一种医疗装置展开系统，其包括限制构件，该限制构件将栓塞保护过滤器保持在限制或部分折叠的状态，用于插入管腔并且转运到期望的部署位置。 约束构件包括两个或更多个部分，其在机械能力方面不同，以抵抗由医疗装置的各部分施加的径向力在其处于受限制或部分塌缩状态时。 约束构件通过致动构件保持在约束构造中，所述致动构件接合位于大致轴向间隙的相对侧上的限制构件的部分，直到需要部署医疗装置。 致动构件的抽出允许约束构件释放医疗装置，然后可以返回到展开状态。 本发明还提供了一种用于组装医疗装置展开系统的方法。

    Medical devices having a coating of biologic macromolecules
    2.
    发明授权
    Medical devices having a coating of biologic macromolecules 有权
    具有生物大分子涂层的医疗器械

    公开(公告)号：US08574612B2

    公开(公告)日：2013-11-05

    申请号：US12708993

    申请日：2010-02-19

    Applicant: Peter Edelman

    Inventor： Peter Edelman

    IPC: A61F2/12 ,  A61K38/02

    CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16

    Abstract: A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.

    Abstract translation: 具有生物大分子涂层的医疗装置。 生物大分子的涂层由位于生物大分子上的临时保护层保护。 临时保护层用于在处理，储存，处理和/或递送期间保护生物大分子的结构（例如，构象）和/或功能（例如，靶结合能力）（例如，植入或插入患者体内） 的医疗器械。 在植入或插入患者体内时，临时保护层可以溶解以将生物大分子暴露于生理环境。

    EMBOLIC FILTER DELIVERY SYSTEM AND METHOD
    4.
    发明申请
    EMBOLIC FILTER DELIVERY SYSTEM AND METHOD 有权
    EMBOLIC过滤器输送系统和方法

    公开(公告)号：US20100152829A1

    公开(公告)日：2010-06-17

    申请号：US12563758

    申请日：2009-09-21

    Applicant: Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eduardo Sucgang

    Inventor： Peter Edelman ,  Lawrence Wasicek ,  Nayan Ashar ,  Husnija Mujkanovic ,  Eduardo Sucgang

    IPC: A61F2/06 ,  A61F2/01

    CPC classification number: A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0048

    Abstract: The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.

    Abstract translation: 本公开涉及一种医疗装置展开系统，其包括限制构件，该限制构件将栓塞保护过滤器保持在限制或部分折叠的状态，用于插入管腔并且转运到期望的部署位置。 约束构件包括两个或更多个部分，其在机械能力方面不同，以抵抗由医疗装置的各部分施加的径向力在其处于受限制或部分塌缩状态时。 约束构件通过致动构件保持在约束构造中，所述致动构件接合位于大致轴向间隙的相对侧上的限制构件的部分，直到需要部署医疗装置。 致动构件的抽出允许约束构件释放医疗装置，然后可以返回到展开状态。 本发明还提供了一种用于组装医疗装置展开系统的方法。

    OFFSET COUPLING REGION
    5.
    发明申请
    OFFSET COUPLING REGION 审中-公开
    偏差耦合区域

    公开(公告)号：US20100152711A1

    公开(公告)日：2010-06-17

    申请号：US12548499

    申请日：2009-08-27

    Applicant: Allen Utke ,  Kyle Hendrikson ,  Peter Edelman ,  Ben Arcand ,  James Anderson ,  Ari Ryan

    Inventor： Allen Utke ,  Kyle Hendrikson ,  Peter Edelman ,  Ben Arcand ,  James Anderson ,  Ari Ryan

    IPC: A61M25/00 ,  A61F2/84 ,  A61M29/00

    CPC classification number: A61F2/95 ,  A61F2/013 ,  A61F2/97 ,  A61F2002/011 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9665

    Abstract: The invention provides a medical device delivery system comprising an offset coupling region interposed between an elongated hypotube guide member or catheter and a support segment. The medical device to be delivered is disposed about the support segment and contained and/or constrained within a containment element. The medical device may be released from the containment element by moving an actuation element from a first position to a second position. The offset coupling region allows the actuation element to exit a lumen within the guide member and to engage the containment element in the first position while traveling along a line generally coaxial with the lumen of the guide member.

    Abstract translation: 本发明提供了一种医疗装置输送系统，其包括插入在细长海波导管构件或导管与支撑段之间的偏置联接区域。 要传送的医疗装置围绕支撑段布置并且包含和/或限制在容纳元件内。 医疗装置可以通过将致动元件从第一位置移动到第二位置而从容纳元件释放。 偏置联接区域允许致动元件离开引导构件内的内腔并且在沿着与引导构件的内腔大致同轴的线的同时沿着第一位置接合容纳元件。

    Biocompatible polymers and hydrogels and methods of use
    9.
    发明申请
    Biocompatible polymers and hydrogels and methods of use 有权
    生物相容性聚合物和水凝胶及其使用方法

    公开(公告)号：US20080095736A1

    公开(公告)日：2008-04-24

    申请号：US11985588

    申请日：2007-11-16

    Applicant: Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

    Inventor： Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

    IPC: A61K31/74 ,  A61P43/00

    CPC classification number: A61K9/0024 ,  A61K31/74 ,  A61K47/34 ,  A61K47/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  C08G63/08 ,  C08G63/912

    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

    Abstract translation: 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。

    MEDICAL DEVICES HAVING A BIORESORBABLE COATING LAYER WITH A PRE-DETERMINED PATTERN FOR FRAGMENTATION
    10.
    发明申请
    MEDICAL DEVICES HAVING A BIORESORBABLE COATING LAYER WITH A PRE-DETERMINED PATTERN FOR FRAGMENTATION 有权
    具有预先确定的图案的可生物降解涂层的医疗装置

    公开(公告)号：US20090274743A1

    公开(公告)日：2009-11-05

    申请号：US12434856

    申请日：2009-05-04

    Applicant: Peter EDELMAN ,  Afsar ALI

    Inventor： Peter EDELMAN ,  Afsar ALI

    IPC: A61L27/54 ,  B05D3/02 ,  A61P9/00 ,  A61F2/84

    CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    Abstract: Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.

    Abstract translation: 包括设置在与医疗装置相关联的衬底上的涂层的血管内医疗装置，其中所述涂层具有预定的碎裂模式。 涂层的至少一部分包括多个不连续的生物可再吸收构件，其中不连续生物可再吸收构件的尺寸小于小动脉的管腔直径。 可以通过挖掘涂层的部分（例如通过激光烧蚀）来形成涂层以产生限定不连续生物可再吸收构件的间隙。 在某些实施方案中，涂层由可热粘合的材料形成。 在这样的实施例中，不连续的生物可再吸收构件可以通过热键粘附到基底上。 还公开了在医疗装置上形成涂层的方法和治疗血管内部位的方法。

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