发明申请
US20100158883A1 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
有权
用于调节血管生成的人氨基-tRNA合成酶多肽
- 专利标题: Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
- 专利标题(中): 用于调节血管生成的人氨基-tRNA合成酶多肽
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申请号: US12655717申请日: 2010-01-06
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公开(公告)号: US20100158883A1公开(公告)日: 2010-06-24
- 发明人: Paul Schimmel , Keisuke Wakasugi
- 申请人: Paul Schimmel , Keisuke Wakasugi
- 专利权人: The Scripps Research Institute
- 当前专利权人: The Scripps Research Institute
- 主分类号: A61K38/43
- IPC分类号: A61K38/43 ; A61K31/7088
摘要:
A method of suppressing angiogenesis in a mammal (e.g., for treating tumors, tumor metastasis or a condition that would benefit from decreased angiogenesis) comprises the step of administering to the mammal an angiostatically effective amount of a pharmaceutical composition comprising an isolated antiangiogenic truncated tryptophanyl-tRNA synthetase (TrpRS) polypeptide or an isolated nucleic acid that comprises a polynucleotide sequence that encodes the truncated TrpRS polypeptide. The truncated TrpRS polypeptide comprises residues 71-471 of SEQ ID NO: 10, residues 48-471 of SEQ ID NO: 10, or a polypeptide of approximately 47 kD molecular weight produced by cleavage of the polypeptide of SEQ ID NO: 10 with polymorphonuclear leucocyte elastase.
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