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1.发明授权Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis 有权可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽公开(公告)号：US08796237B2
公开(公告)日：2014-08-05
申请号：US13229866
申请日：2011-09-12
IPC分类号： C07H21/04 , C07K14/515
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： The invention provides an isolated nucleic acid encoding a polypeptide capable of inhibiting angiogenesis or neovascularization, wherein the nucleic acid comprises a first polynucleotide sequence comprising a coding sequence at least 95 percent identical to a sequence selected from the group consisting of a polynucleotide SEQ ID NO:6, a polynucleotide that encodes a polypeptide of SEQ ID NO:12, and a polynucleotide that encodes a fragment of the polypeptide of SEQ ID NO:12; and wherein the nucleic acid does not encode for the amino acid sequence of amino acids 71-93 of SEQ ID NO:1. Pharmaceutical compositions, vectors, and methods for inhibiting neovascularization or angiogenesis comprising or utilizing the nucleic acids also are provided.
摘要翻译： 本发明提供了编码能够抑制血管生成或新生血管形成的多肽的分离的核酸，其中所述核酸包含第一多核苷酸序列，所述第一多核苷酸序列包含与选自多核苷酸SEQ ID NO： 6，编码SEQ ID NO：12的多肽的多核苷酸和编码SEQ ID NO：12的多肽的片段的多核苷酸; 并且其中所述核酸不编码SEQ ID NO：1的氨基酸71-93的氨基酸序列。 还提供了用于抑制新生血管形成或血管发生的药物组合物，载体和方法，其包含或利用核酸。
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2.发明授权Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis 有权可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽公开(公告)号：US08017593B2
公开(公告)日：2011-09-13
申请号：US12319822
申请日：2009-01-13
IPC分类号： A61K48/00
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.
摘要翻译： 本发明提供一种抑制患者眼新生血管形成的方法。 该方法包括向患者施用眼新生血管形成抑制量的选自SEQ ID NO：12，SEQ ID NO：7的水溶性多肽和其新生血管形成抑制片段，其包括至少一种 氨基酸残基特征序列HVGH（SEQ ID NO：10）和KMSAS（SEQ ID NO：11）。 还提供了用于测定组合物的血管发生抑制活性的方法。
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3.发明申请Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis 有权可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽公开(公告)号：US20090275643A1
公开(公告)日：2009-11-05
申请号：US12319822
申请日：2009-01-13
IPC分类号： A61K31/711 , G01N33/483
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided
摘要翻译： 本发明提供一种抑制患者眼新生血管形成的方法。 该方法包括向患者施用眼新生血管形成抑制量的选自SEQ ID NO：12，SEQ ID NO：7的水溶性多肽和其新生血管形成抑制片段，其包括至少一种 氨基酸残基特征序列HVGH（SEQ ID NO：10）和KMSAS（SEQ ID NO：11）。 还提供了用于测定组合物的血管发生抑制活性的方法
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4.发明授权Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis 有权可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽公开(公告)号：US07273844B2
公开(公告)日：2007-09-25
申请号：US10982014
申请日：2004-11-04
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). Methods of using the polypeptide to inhibit angiogenesis are also provided.
摘要翻译： 人色氨酰-tRNA合成酶的分离的水溶性多肽片段可用于抑制血管发生。 该多肽具有SEQ ID NO：7，SEQ ID NO：12所示的氨基酸残基或其血管生成抑制片段，该片段包括氨基酸残基特征序列HVGH（SEQ ID NO：10）和 KMSAS（SEQ ID NO：11）。 还提供了使用该多肽抑制血管生成的方法。
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5.发明申请Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权用于调节血管生成的人氨基-tRNA合成酶多肽公开(公告)号：US20070048322A1
公开(公告)日：2007-03-01
申请号：US11590434
申请日：2006-10-31
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , A61K48/00 , A61K39/395 , C12N9/22 , C07K16/40
摘要： Nucleic acids encoding tRNA synthetase polypeptides useful for regulating angiogenesis are disclosed. Methods of making and using such nucleic acids are also disclosed.
摘要翻译： 公开了编码用于调节血管发生的tRNA合成酶多肽的核酸。 还公开了制备和使用这些核酸的方法。
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6.发明授权Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权用于调节血管生成的人氨基-tRNA合成酶多肽公开(公告)号：US07144984B2
公开(公告)日：2006-12-05
申请号：US10240527
申请日：2001-03-21
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
摘要： Compositions comprising tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
摘要翻译： 描述了包含可用于调节血管发生的tRNA合成酶多肽的组合物，以及编码这种tRNA合成酶多肽的核酸。 还公开了制备和使用这些组合物的方法。
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7.发明申请Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis 有权可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽公开(公告)号：US20050197298A1
公开(公告)日：2005-09-08
申请号：US10982014
申请日：2004-11-04
IPC分类号： A61K38/00 , C07H21/04 , C07K14/515 , C07K14/52 , C12N9/00 , A61K38/08 , A61K48/00 , C12N9/22 , C12Q1/68
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). Methods of using the polypeptide to inhibit angiogenesis are also provided.
摘要翻译： 人色氨酰-tRNA合成酶的分离的水溶性多肽片段可用于抑制血管发生。 该多肽具有SEQ ID NO：7，SEQ ID NO：12所示的氨基酸残基或其血管生成抑制片段，该片段包括氨基酸残基特征序列HVGH（SEQ ID NO：10）和 KMSAS（SEQ ID NO：11）。 还提供了使用该多肽抑制血管生成的方法。
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8.发明申请COMPOSITIONS AND METHODS FOR TREATING CHARCOT-MARIE-TOOTH DISEASES AND RELATED NEURONAL DISEASES 审中-公开治疗精神病虫害及相关神经疾病的组合物和方法公开(公告)号：US20160144003A1
公开(公告)日：2016-05-26
申请号：US14781563
申请日：2012-05-17
申请人： Xiang-lei Yang , Paul Schimmel , Weiwei He
发明人： Xiang-lei Yang , Paul Schimmel , Weiwei He
IPC分类号： A61K38/53
CPC分类号： A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/93
摘要： Provided are compositions and methods for the treatment of mutant glycyl-tRNA synthetase (GlyRS)-associated diseases, such as Charcot-Marie-Tooth (CMT) diseases, and related compositions and methods for diagnostic, drug discovery, and research applications. Also provided are mutant glycyl-tRNA synthetases and uses thereof.
摘要翻译： 提供了用于治疗突变型糖基-tRNA合成酶（GlyRS）相关疾病如Charcot-Marie-Tooth（CMT）疾病的组合物和方法以及用于诊断，药物发现和研究应用的相关组合物和方法。 还提供突变体甘氨酰-tRNA合成酶及其用途。
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9.发明授权Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权用于调节血管生成的人氨基-tRNA合成酶多肽公开(公告)号：US08562977B2
公开(公告)日：2013-10-22
申请号：US13434933
申请日：2012-03-30
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521
摘要： Pharmaceutical compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis an nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
摘要翻译： 描述了包含用于调节血管生成的截短的色氨酰-tRNA合成酶多肽的药物组合物，其编码这种tRNA合成酶多肽的核酸。 还公开了制备和使用这些组合物的方法。
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10.发明申请TRYPTOPHANYL-tRNA SYNTHETASE-DERIVED POLYPEPTIDES USEFUL FOR THE REGULATION OF ANGIOGENESIS 有权用于调节血管生成的TRYPTOPHANYL-tRNA合成酶衍生的多肽公开(公告)号：US20120238620A1
公开(公告)日：2012-09-20
申请号：US13229866
申请日：2011-09-12
IPC分类号： A61K31/713 , C12N15/861 , C12N15/869 , C12N15/863 , A61P9/00 , C12N5/10 , C12N1/19 , C12N1/15 , C12N1/21 , C12N15/52 , C12N15/85 , C12N15/867
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： The invention provides an isolated nucleic acid encoding a polypeptide capable of inhibiting angiogenesis or neovascularization, wherein the nucleic acid comprises a first polynucleotide sequence comprising a coding sequence at least 95 percent identical to a sequence selected from the group consisting of a polynucleotide SEQ ID NO:6, a polynucleotide that encodes a polypeptide of SEQ ID NO:12, and a polynucleotide that encodes a fragment of the polypeptide of SEQ ID NO:12; and wherein the nucleic acid does not encode for the amino acid sequence of amino acids 71-93 of SEQ ID NO:1. Pharmaceutical compositions, vectors, and methods for inhibiting neovascularization or angiogenesis comprising or utilizing the nucleic acids also are provided.
摘要翻译： 本发明提供了编码能够抑制血管生成或新生血管形成的多肽的分离的核酸，其中所述核酸包含第一多核苷酸序列，所述第一多核苷酸序列包含与选自多核苷酸SEQ ID NO： 6，编码SEQ ID NO：12的多肽的多核苷酸和编码SEQ ID NO：12的多肽的片段的多核苷酸; 并且其中所述核酸不编码SEQ ID NO：1的氨基酸71-93的氨基酸序列。 还提供了用于抑制新生血管形成或血管发生的药物组合物，载体和方法，其包含或利用核酸。
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