发明申请
- 专利标题： Transforming Growth Factor Modulators
- 专利标题（中）： 转化生长因子调节剂
-
申请号： US12086954申请日： 2006-12-22
-
公开(公告)号： US20100166819A1公开(公告)日： 2010-07-01
- 发明人: Wen-Cherng Lee , Lihong Sun , Michael Hoemann , Deqiang Niu , Dingxue Yan , Claudio Chuaqui , Russell Petter , Helen (Xiaomei) Feng
- 申请人： Wen-Cherng Lee , Lihong Sun , Michael Hoemann , Deqiang Niu , Dingxue Yan , Claudio Chuaqui , Russell Petter , Helen (Xiaomei) Feng
- 专利权人： Biogen Idec MA Inc. a corporation
- 当前专利权人： Biogen Idec MA Inc. a corporation
- 国际申请： PCT/US2006/049169 WO 20061222
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K9/00 ; A61K31/502 ; A61K31/517 ; A61K31/438 ; C07D487/10 ; C07D401/14 ; C07D403/14 ; A61P35/00 ; A61P9/12 ; A61P9/10 ; A61P27/02 ; A61P1/16 ; A61P13/12
摘要：
The invention is related to compounds of formula (I) that can be used as antagonists of the TGFβ family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.
信息查询
