Invention Application
- Patent Title: Transforming Growth Factor Modulators
- Patent Title (中): 转化生长因子调节剂
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Application No.: US12086954Application Date: 2006-12-22
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Publication No.: US20100166819A1Publication Date: 2010-07-01
- Inventor: Wen-Cherng Lee , Lihong Sun , Michael Hoemann , Deqiang Niu , Dingxue Yan , Claudio Chuaqui , Russell Petter , Helen (Xiaomei) Feng
- Applicant: Wen-Cherng Lee , Lihong Sun , Michael Hoemann , Deqiang Niu , Dingxue Yan , Claudio Chuaqui , Russell Petter , Helen (Xiaomei) Feng
- Assignee: Biogen Idec MA Inc. a corporation
- Current Assignee: Biogen Idec MA Inc. a corporation
- International Application: PCT/US2006/049169 WO 20061222
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K9/00 ; A61K31/502 ; A61K31/517 ; A61K31/438 ; C07D487/10 ; C07D401/14 ; C07D403/14 ; A61P35/00 ; A61P9/12 ; A61P9/10 ; A61P27/02 ; A61P1/16 ; A61P13/12
Abstract:
The invention is related to compounds of formula (I) that can be used as antagonists of the TGFβ family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.
Information query
