公开(公告)号：US20100159455A1

公开(公告)日：2010-06-24

申请号：US12441672

申请日：2007-09-18

Applicant: Tanya Landsman ,  David J. Livingston ,  Richard A. Martinelli ,  Yumei Huang ,  Benjamin Adam Seigal ,  Dingxue Yan ,  James M. Coull ,  Andrew M. Stern

Inventor： Tanya Landsman ,  David J. Livingston ,  Richard A. Martinelli ,  Yumei Huang ,  Benjamin Adam Seigal ,  Dingxue Yan ,  James M. Coull ,  Andrew M. Stern

IPC: C12Q1/68

CPC classification number: G01N33/542 ,  C12Q1/6804 ,  G01N33/566 ,  G01N2333/71 ,  C12Q2565/101 ,  C12Q2563/179 ,  C12Q2563/131

Abstract: The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.

Abstract translation: 本发明提供组合物和方法，例如测定技术及其在生物检测和诊断中的应用。 更具体地，本发明提供了基于生物检测和受体（及其家族）和蛋白质（及其家族）的生物检测和分析的核酸模板化学的组合物和方法，以及其在诊断中的用途。

公开(公告)号：US06402986B1

公开(公告)日：2002-06-11

申请号：US09354891

申请日：1999-07-16

Applicant: Guilford Jones, II ,  Dingxue Yan

Inventor： Guilford Jones, II ,  Dingxue Yan

IPC: C09K1106

CPC classification number: G01N21/6408 ,  C09D11/50

Abstract: This patent disclosure describes novel compositions and methods used in the verification of products or documents based on the reading of emitted light from luminescent compositions that can be incorporated or applied to a wide variety of materials. Specifically, the compositions are uniquely luminescent at various wavelengths, displaying qualities of image, wavelength, and time scale for the measure of luminesce decay. The light emitted from the composition, and specifically, the measure of the variable and adjustable luminescence lifetimes provides a multi-parameter signature for purposes of comparative light decay analysis of verification marks or features.

Abstract translation: 该专利公开描述了基于从可以掺入或应用于各种各样的材料的发光组合物的发射光的读取中用于验证产品或文献的新型组合物和方法。 具体地，组合物在各种波长下是唯一发光的，显示用于测量发光衰变的图像质量，波长和时间尺度。 从组合物发射的光，具体地，可变和可调节的发光寿命的测量提供了用于验证标记或特征的比较光衰减分析的多参数签名。

公开(公告)号：US20100166819A1

公开(公告)日：2010-07-01

申请号：US12086954

申请日：2006-12-22

Applicant: Wen-Cherng Lee ,  Lihong Sun ,  Michael Hoemann ,  Deqiang Niu ,  Dingxue Yan ,  Claudio Chuaqui ,  Russell Petter ,  Helen (Xiaomei) Feng

Inventor： Wen-Cherng Lee ,  Lihong Sun ,  Michael Hoemann ,  Deqiang Niu ,  Dingxue Yan ,  Claudio Chuaqui ,  Russell Petter ,  Helen (Xiaomei) Feng

IPC: A61K31/55 ,  A61K9/00 ,  A61K31/502 ,  A61K31/517 ,  A61K31/438 ,  C07D487/10 ,  C07D401/14 ,  C07D403/14 ,  A61P35/00 ,  A61P9/12 ,  A61P9/10 ,  A61P27/02 ,  A61P1/16 ,  A61P13/12

CPC classification number: C07D487/10 ,  C07D471/10

Abstract: The invention is related to compounds of formula (I) that can be used as antagonists of the TGFβ family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.

Abstract translation: 本发明涉及可用作TGFβb拮抗剂的式（I）化合物; 家族I型受体，Alk5和/或Alk4，组合物和使用方法。 式（I）化合物可用于预防和/或治疗诸如纤维化（例如肾纤维化，肺纤维化和肝纤维化），进行性癌症或其它TGFβb的降低的疾病; 家庭信号传导活动是可取的。