发明申请
- 专利标题： Potassium channel mutants of the yeast Saccharomyces cerevisiae and their use for screening eukaryotic potassium channels
- 专利标题（中）： 酵母酿酒酵母的钾通道突变体及其用于筛选真核钾通道的用途
-
申请号： US12121900申请日： 2008-05-16
-
公开(公告)号： US20100167275A1公开(公告)日： 2010-07-01
- 发明人: Ekkehard Leberer , Thomas Leeuw , Allegra Ritscher
- 申请人： Ekkehard Leberer , Thomas Leeuw , Allegra Ritscher
- 专利权人： sanofi-aventis Deutschland GmbH
- 当前专利权人： sanofi-aventis Deutschland GmbH
- 优先权： DE10000651 20000111
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/02 ; C12Q1/06 ; C12N1/19
摘要：
The invention relates to processes for identifying inhibitors and activators of eukaryotic potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous potassium channels TRK1, TRK2 and TOK1 are not expressed functionally, but which expresses heterologously a eukaryotic potassium channel to be studied. Other subject matters of the invention are mutated S. cerevisiae cells which do not express TRK1, TRK2 and TOK1, and the preparation and use of these mutated S. cerevisiae cells.