发明申请
US20100168210A1 T-Cell Cytokine-Inducing Surface Molecules and Methods of Use
审中-公开
T细胞细胞因子诱导表面分子及其使用方法
- 专利标题： T-Cell Cytokine-Inducing Surface Molecules and Methods of Use
- 专利标题（中）： T细胞细胞因子诱导表面分子及其使用方法
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申请号： US12663328申请日： 2008-06-05
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公开(公告)号： US20100168210A1公开(公告)日： 2010-07-01
- 发明人: Carl Keith Edwards, III , Li Li , Karen R. Jonscher , David Norris
- 申请人： Carl Keith Edwards, III , Li Li , Karen R. Jonscher , David Norris
- 国际申请： PCT/US08/65992 WO 20080605
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P19/02 ; A61P35/00 ; A61P17/06 ; A61P3/10 ; A61P11/06 ; A61P31/18 ; A61P31/12
摘要：
The invention provides cytokine modulators and methods for using the same to modulate cytokine production in monocyte lineage-derived cells. In particular, cytokine modulators of the invention selectively bind to a T-cell cytokine-inducing surface molecule (TCISM)-ligand of T lymphocytes or the corresponding TCISM-receptor of monocyte lineage-derived cells, thereby modulating cytokine production in monocyte lineage-derived cells.
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