摘要:
The invention provides cytokine modulators and methods for using the same to modulate cytokine production in monocyte lineage-derived cells. In particular, cytokine modulators of the invention selectively bind to a T-cell cytokine-inducing surface molecule (TCISM)-ligand of T lymphocytes or the corresponding TCISM-receptor of monocyte lineage-derived cells, thereby modulating cytokine production in monocyte lineage-derived cells.
摘要:
The present disclosure provides methods and compositions for modulating an adaptive immune response without significantly affecting an innate immunity response in a subject by modulating a combination of an Immunophilin/Cyclophilin Family Member and an EMMPRIN Immunoglobulin Receptor Superfamily Member. The present invention also provides methods and compositions for treating a variety of clinical conditions by modulating an Immunophilin/Cyclophilin Family Member and an EMMPRIN Immunoglobulin Receptor Superfamily Member.
摘要:
An intelligent module pipeline, an intelligent module helical pipeline winding machine and a winding method thereof. In the cross section of the pipeline, a plurality of intelligent modules (1) are clamped and helically wound end to end to form a circular pipeline; each of the intelligent module units is an arch-shaped module which is formed by injection molding or compression molding; the each intelligent module unit is provided a reinforcing rib structure inside, a fixing device for fixing and clamping from left to right on the side surfaces, and a clamping device for fixing and clamping end to end at the edges. An arc-shaped chute rail is provided on the front surface of a working panel of the winding machine; the arc-shaped chute rail is provided with at least one pair of feed rollers (107), and is further provided with a locking device (108) and a parallel twisting device (106); the same intelligent module units are arranged end to end on the arc-shaped chute rail, and then are locked by means of the locking device, to form a semicircular pipe diameter by means of the feed rollers; then the parallel twisting device twists the semicircular pipe diameter in parallel to change the winding rail; and the intelligent module units are wound in a staggered arrangement to form helical winding pipelines.
摘要:
A method computer implemented method of minimizing connections in a distributed system includes traversing paths in a directed graph representation of the distributed system having a fixed set of paths between nodes representing resources of the distributed system and edges representing connections between the resources by performing a random walk procedure to provide a reduced number of paths in the directed graph representation, and identifying excessive connections between the resources by simulating a client accessing the resources and identifying as excessive, connections that are not used by any of the reduced number of paths, wherein the excessive connections are removable from the distributed system without preventing client access to resources in the distributed system.
摘要:
The present invention relates to a smart textile capable of providing acupuncture therapy to the wearer through strategically positioned electrodes throughout the textile, connected via silver coated fabric. Through the instant invention, heat therapy can be applied to specific points on the body, while being safe due to the absence of wires.
摘要:
The present disclosure relates to, inter alia, an easy-to-operate, fully closed component, which can be part of an instrument, for purification of biomolecules from biological samples, and subsequent transfer, and testing of the biomolecules, as well as an instrument comprising the component, and a method for using the component.
摘要:
Method to transport HTPP over XMPP, including: forming a first two-level URI template to identify web resources accessible by use of HTTP in an XMPP network, wherein a first level is XMPP-formatted and a second level is HTTP-formatted; binding HTTP to XMPP and stanzas; transmitting the HTTP messages in those stanzas; receiving a HTTP messages in those stanzas; and a XMPP mechanism to discover if an XMPP entity supports transporting HTTP over XMPP.
摘要:
This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要:
A retrofit-style lamp is disclosed. The retrofit-style lamp includes a plurality of light sources, and a one-dimensional linear batwing lens. The one-dimensional linear batwing lens beam shapes light emitted by at least two light sources of the plurality of light sources. The retrofit-style lamp also includes a housing including the plurality of light sources, and attached to the one-dimensional linear batwing lens. The combination of housing and lens is then itself fitted with endcaps, including electrical connectors, for placement within a fixture, such as within an existing conventional fluorescent tube fixture located within a storage structure, for example a refrigeration case. Alternatively, the plurality of light sources, the one-dimensional linear batwing lens, and the housing may be formed, along with a power supply, as a standalone retrofit fixture for use in enclosed storage structures, such as refrigeration cases, where the retrofit fixture replaces a conventional fluorescent fixture.