Invention Application
US20100168398A1 Method, computing routine, device for predicting properties of MHC/peptide complexes, and data and peptides produced therefrom.
审中-公开
方法，计算程序，用于预测MHC /肽复合物的性质的装置，以及由其制备的数据和肽。
- Patent Title: Method, computing routine, device for predicting properties of MHC/peptide complexes, and data and peptides produced therefrom.
- Patent Title (中): 方法，计算程序，用于预测MHC /肽复合物的性质的装置，以及由其制备的数据和肽。
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Application No.: US12660774Application Date: 2010-03-04
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Publication No.: US20100168398A1Publication Date: 2010-07-01
- Inventor: Ignace Lasters , Johan Desmet
- Applicant: Ignace Lasters , Johan Desmet
- Priority: EP02447115.3 20020610
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K14/00 ; C07H21/04 ; C12P21/06 ; G06F17/50 ; G06F17/10 ; G06N5/04
Abstract:
The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.
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