发明申请
- 专利标题： NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES
- 专利标题（中）： 新型异喹啉化合物可用于制备联合中药和相关中间体
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申请号： US12598378申请日： 2008-05-01
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公开(公告)号： US20100168431A1公开(公告)日： 2010-07-01
- 发明人: Vladimir Naddaka , Shen Jingshan , Oded Arad , Guo Hongli , Ofer Sharon , Eyal Klopfer , Shady Saeed
- 申请人： Vladimir Naddaka , Shen Jingshan , Oded Arad , Guo Hongli , Ofer Sharon , Eyal Klopfer , Shady Saeed
- 申请人地址： IL Bnei Brak
- 专利权人： Chemagis Ltd.
- 当前专利权人： Chemagis Ltd.
- 当前专利权人地址： IL Bnei Brak
- 国际申请： PCT/IL2008/000586 WO 20080501
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D217/16
摘要：
The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification
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